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Liposomes as Anticancer Therapeutic Drug Carrier’s Systems: More than a Tour de Force

[ Vol. 10 , Issue. 2 ]

Author(s):

Mahfoozur Rahman, Sarwar Beg, Amita Verma, Imran Kazmi, Farhan Jalees Ahmed, Vikas Kumar, Firoz Anwar and Sohail Akhter*   Pages 178 - 185 ( 8 )

Abstract:


A liposome is a spherical vesicle composed of a bilayer of lipid with central aqueous cavity. Liposomes are the first nano vesicular drug delivery carriers, which are successfully translated into real-time clinical application and gained great potential in the past 30 years. The characteristics of liposomes to encapsulate both hydrophilic and hydrophobic drugs, their biocompatibility and biodegradability make it attractive nanocarriers in drug delivery area. Apart from this, great technical advancement has been made to develops second-generation liposomes named as stealth liposomes, cationic liposomes, triggered release liposomes and ligand targeted liposomes. This led to widespread use of liposomes in various areas including anticancer therapeutics, diagnostics and imaging agents. Therefore, the presents review article made an extensive discussion of various liposomes and its applications in cancer treatment.

Keywords:

Phospholipids, Liposomes, ligand targeted liposomes, Cancer, Anticancer drug, and Doxil.

Affiliation:

Department of Pharmaceutical Science, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, Nanomedicine Research lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Department of Pharmaceutical Science, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, Nanomedicine Research lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Department of Pharmaceutical Science, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, Department of Pharmaceutical sciences, Siddharta Institute of Pharmacy, Dehradun, Centre de Biophysique Moléculaire (CBM)-CNRS UPR4301/University of Orléans Rue Charles Sadron, 45071 Orléans, Cedex 2



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